Prairie South School Division has 40 schools located within 24 rural and urban communities. The Division encompasses 32,747 square kilometres (12,643 square miles) of southern Saskatchewan. It spans a geographic area from Coronach in the South, Mankota in the West, Rouleau in the East and Craik in the North.

The Division is divided into six subdivisions for purposes of board representation. Prairie School Division encompasses rural and urban communities with one large city at its heart, Moose Jaw, where the school division head office, learning department, maintenance and one transportation office is located. Five Hutterian colonies and two associate schools are also located within the Division boundaries.